Abstract
Solid-phase synthesis of imidazolyl-beta-amino acid derivatives is described. Several analogs demonstrated moderate inhibition of geranylgeranyl protein transferase type I (GGPT I).
MeSH terms
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Alkyl and Aryl Transferases / antagonists & inhibitors*
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Amino Acids / chemical synthesis*
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Amino Acids / pharmacology*
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Inhibitory Concentration 50
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Models, Chemical
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Molecular Structure
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Structure-Activity Relationship
Substances
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Amino Acids
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Alkyl and Aryl Transferases
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geranylgeranyltransferase type-I